WBC extremly elevated, bone marrow gone mad?
Hi, this is a long story...
Female lutino budgie, 3 years old. First symptom was 1,5 years ago - weight loss, tired, eating alot, sometimes throwing up and passing undigested seeds. Got better when fed oat soaked in water over night with a dash of rape seed oil. Got better. Got back, got better and so on. Treated her with apple cider vineagar (suspected magabacteria) got better, saw an avian vet, grams stains from crop an feaces came back negative, she got vitamin injections (A, D, E + B1, B6, B12) got better, stayed well for 5-6 months and then again; tired, weight loss, ,eating a lot, sometimes throwing up and passing undigested seeds. Saw a vet again (not avian). WBC was poorly done and marked "plenty of smudge cells" total WBC 1000 monocytes 28% and therefore given Bactrim (trim+sulph), got stronger, gained weight, got well! Converted to Harrison's high potency. New WBC to se that all was good, in May; 25 000!
Then two months later (july) I took the budgie to this true avian vet. WBC was 75 000. Monocytes 12 800, some toxic heterophiles, some immature heterophiles. Red blood cells looked normal, hematocrit was 45%. She was given vitamin injections as the year before and put on orally doxycycline for 45 days. Ten days after the last medicine given, this week accullay, new WBC was taken. Smudge cells. WBC is now 84 000. Monocytosis. Many of the monocytes looks immature as do many red blood cells. Hematocrit 40%. The vet took pictures of the smear and has sent them to other vets around the world for help in assesment of the WBC and diff. Never seen so high WBC and odd diff for a budgie! My vet thinks that this is neoplasia, that her bone marrow has gone mad. Infection is not at all likley he says. Due to X-rays showing slow bowel movments and crop emptying, it could be borna virus, polyomavirus? That is treatable with NSAID and motility stimulants he says. However, that is not really what the WBC says.
I can't get this straight! Why has her bone marrow suddenly gone mad? Has is it really? Why was noting suscpeted on the former WBC? Shouldn't it had been seen if it was so? All cells except a few heterophils were mature! The WBC has changed so strangley.. Tell me about WBC and avian heamatology!
Have you any input on this? What is this with the bone marrow? Can you tell me of this condition called neoplasia?